In this special issue we aim to review replicating competent reporter expressing viruses belonging to different families methods of characterization and applications to facilitate the study of in vitro and in vivo viral infections contrasting advantages we also seek to discuss disadvantages associated with these reporter expressing viruses. Despite moderate attenuation in vitro relative to the wt virus the viruses expressing a viral fusion protein vp gluc1 or vp gluc2 were replication competent with the vp gluc1 viruses showing higher titers than their vp gluc2 counterparts upon multi cycle amplification on mdck cells . To circumvent this requirement replication competent iav expressing an easily traceable reporter protein can be used here we discuss the development and applications of recombinant replication competent iav harboring diverse fluorescent or bioluminescent reporter genes in different locations of the viral genome. Replication competent influenza a viruses expressing reporter genes article literature review pdf available in viruses 87179 june 2016 with 2205 reads how we measure reads. Influenza a viruses iav cause annual seasonal human respiratory disease epidemics in addition iav have been implicated in occasional pandemics with inordinate health and economic consequences studying iav in vitro or in vivo requires the use of laborious secondary methodologies to identify virus infected cells to circumvent this requirement replication competent iav expressing an
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